Fermentation suite – up to 10 L capacity with steam-in-place (SIP) and clean-in-place (CIP) facilities; 10 L system and a 2 L quad fermentation unit. Can be set up for microbial cell culture but also has microspargers and marine-type impellers for conversion to animal cell culture. All the fermenters have pH, P02, turbidity and off gas analysis which feeds back to a MFCS data handling unit. For downstream processing there is a centrifuge (50L/hr, 11,750 rpm) and a Millipore TFF unit for concentrating down product, depending on the process.
BIOSTAT Cultibag RM 20/50 – This is a wave technology / disposable bag system for animal cell culture, up to 20 L capacity currently, with 50 L possible with additional equipment.
Solid formulations – 5 vessels ranging from 250 L to 500 L; training instrumentation skid, centrally controlled by a PLC with SCADA interface for the user.
Other equipment in the PP includes:
- Milipore K-Prime unit for larger scale chromatography projects
- Bottling line with 500ml fill capacity fed from the main vessels in the lab
- Pasteurising Unit as part of the main lab with a 500L holding tank to maintain temperature.